The study partner must have sufficient contact such that the investigator feels the study partner can provide meaningful information about the participant's daily function Has a study partner that is willing to participate as a source of information and has approximately weekly contact with the participant (contact can be in-person, via telephone or electronic communication).
A45 Trial: Elevated brain amyloid pathology by amyloid PET: defined as approximately greater than (>) 40 Centiloids on screening scan A3 Trial: Intermediate levels of brain amyloid pathology by amyloid PET: defined as approximately 20 to 40 Centiloids on screening scan.Wechsler Memory Scale-Revised Logical Memory subscale II (WMS-R LM II) score at screening of >=6.Those 55 to 64 must have 1 of the following additional risk factors, given the relatively low rates of amyloid positivity less than (=) 27 (with educational adjustments) at screening.Male or female, age 55 to 80 years inclusive at the time of informed consent, with a plasma biomarker result that is predictive of intermediate or elevated brain amyloid at Screening or known before Screening to have elevated or intermediate amyloid according to previous PET, cerebrospinal fluid (CSF), or plasma testing Participants must meet all of the following criteria to be included in this study: A3 Trial: Change From Baseline in Amyloid Positron Emission Tomography (PET) Standard Uptake Value Ratio (SUVr) at Week 216.
PACC5(5 components):Free/cued selective reminding test:number of words recalled without cuing/with cuing(0-96) Delayed Paragraph Recall test: recall of 1 short story(25 bits information),immediately after reading and again after delay of 30 minutes (0-25) Digit-symbol substitution test: Participant uses a key to fill in blank squares as fast as possible in 90 seconds(0-91) Mini Mental State Score:to evaluate orientation,memory,attention,concentration,naming,repetition,comprehension and ability to create sentence,to copy 2 overlapping pentagons, scored as number of correctly completed items(0-30) Category fluency task: participants generate words in 60 second belonging to a semantic category(total score:number of appropriate words generated per task, higher values indicate better performance).
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